Endocrine Abstracts

Background: Iodine deficiency is the most important exogenous factor for the development of goiters and thyroid nodules. In addition, family and twin studies as well as linkage analyses and a genome-wide scan in 18 euthyroid goiter families suggest a genetic predisposition for euthyroid goiters. However, data about the inheritance of goiters are still contradictory. Therefore, we investigated goiter predisposition by a matched case control study.Patients...

Objective: There are contradictory results regarding the possible association of the TSHR polymorphism D727E with TMNG. Furthermore the influence of smoking on the thyroid volume has been reported by several authors. A possible association of smoking with thyroid nodules and particularly TMNG has not been investigated up to date.Methods: In this study, 88 patients with TMNG were included. Diagnosis was verified by ultrasonography, scinthiscan, and measur...